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Translational Medicine / 转化医学Senolytic Therapy Clinical Research

Jan van Deursen

PhD

🏢Unity Biotechnology / Mayo Clinic (former)🌐USA

Scientific Founder and Former Chair of Biochemistry and Molecular Biology

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👥Biography 个人简介

Jan van Deursen provided the original proof-of-concept that genetic clearance of p16INK4a-positive senescent cells extends healthspan and delays cancer in the INK-ATTAC mouse model, catalyzing the entire senolytic therapy field. His BubR1 progeroid mouse studies demonstrated that senescent cell accumulation drives premature aging phenotypes including cancer susceptibility. He co-founded Unity Biotechnology to translate senolytic approaches to clinical medicine.

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🧪Research Fields 研究领域

p16INK4a senescence
BubR1 progeroid mouse model
INK-ATTAC transgenic system
Senescent cell imaging
Proof-of-concept senolysis

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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