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Translational Medicine / 转化医学Immunotherapy, Predictive Biomarkers

Valsamo Anagnostou

MD, PhD

🏢Johns Hopkins Sidney Kimmel Comprehensive Cancer Center🌐USA

Associate Professor of Oncology

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👥Biography 个人简介

Valsamo Anagnostou investigates the molecular determinants of durable immunotherapy response and has contributed to understanding how ARID1A chromatin remodeler mutations enhance tumor immunogenicity and IO sensitivity. Her research on clonal neoantigen evolution during immunotherapy treatment has contributed to understanding acquired resistance mechanisms. She utilizes ctDNA dynamics to monitor IO response and resistance evolution longitudinally in clinical trials. Anagnostou's multi-omic biomarker approach integrates genomics, transcriptomics, and proteomics for comprehensive IO biomarker discovery at Hopkins.

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🧪Research Fields 研究领域

ARID1A mutations IO response
chromatin remodeling IO biomarker
clonal neoantigen evolution IO
ctDNA IO response monitoring
multi-omic IO biomarkers

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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