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Translational Medicine / 转化医学Hyaluronic Acid, ECM, TME

Valeria Bhatt

PhD

🏢Memorial Sloan Kettering Cancer Center🌐USA

Assistant Professor of Oncology

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Key Papers
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Key Contributions

👥Biography 个人简介

Valeria Bhatt studies how hyaluronic acid accumulation in the tumor ECM creates a physical and biological barrier to drug delivery and immune infiltration. Her research has characterized how high hyaluronic acid content in pancreatic, colorectal, and breast tumors drives desmoplasia and limits therapeutic access. She evaluated PEGPH20 (PEGylated hyaluronidase) and related strategies to degrade tumor hyaluronic acid and improve drug delivery. Her work informs combination approaches targeting ECM components with systemic therapies.

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🧪Research Fields 研究领域

hyaluronic acid
ECM remodeling
tumor microenvironment
desmoplasia
stromal barriers

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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