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Translational Medicine / 转化医学Bifunctional Antibody Engineering

Umesh Bhatt

PhD

🏢AbbVie Bioresearch Center🌐USA

Director of Bispecific Antibody Chemistry

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👥Biography 个人简介

Umesh Bhatt leads bispecific antibody chemistry and formulation development at AbbVie, optimizing the pharmaceutical properties of novel bispecific and multispecific antibody formats for clinical development. His work on dual variable domain immunoglobulin technology and other bispecific formats has addressed key CMC challenges including protein stability, aggregation, and manufacturability. He has contributed to advancing multiple bispecific antibody candidates through the chemistry, manufacturing, and controls requirements for clinical and commercial development.

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🧪Research Fields 研究领域

Bispecific antibody formulation
Dual variable domain antibodies
Antibody stability engineering
Bispecific CMC development
Multispecific molecule characterization

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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