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Translational Medicine / 转化医学Tumor Organoid Drug Screening

David Tuveson

MD, PhD

🏢Cold Spring Harbor Laboratory🌐USA

Director of Cold Spring Harbor Cancer Center

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👥Biography 个人简介

David Tuveson has pioneered pancreatic cancer organoid models that faithfully recapitulate the dense stromal microenvironment and drug resistance characteristic of pancreatic ductal adenocarcinoma. His organoid co-culture systems incorporating cancer-associated fibroblasts and immune cells enable testing of combination therapies in physiologically relevant conditions. His work has accelerated clinical translation of organoid-guided therapy for pancreatic cancer patients.

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🧪Research Fields 研究领域

Pancreatic cancer organoids
KRAS-driven tumor modeling
Organoid co-culture systems
Stroma-tumor interactions
Preclinical drug testing

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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