Tullia C. Bruno
图利亚·布鲁诺
PhD
Assistant Professor, Department of Immunology; Member, Tumor Microenvironment Center免疫学系助理教授；肿瘤微环境中心成员
👥Biography 个人简介
Immunologist specializing in regulatory T cell biology and IL-35-mediated immunosuppression within the tumor microenvironment. Her work elucidates how Tregs enforce checkpoint resistance and identifies combination strategies to relieve immunosuppression and restore anti-tumor immunity.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
IL-35 in Tumor Immunity
Defined the role of tumor-infiltrating regulatory T cell-derived IL-35 in promoting immune evasion, demonstrating that IL-35 blockade can restore effector T cell function and synergize with checkpoint inhibitors.
Regulatory T Cell Heterogeneity
Characterized distinct Treg subpopulations within human tumors using high-dimensional profiling, revealing subset-specific suppressive mechanisms that contribute differentially to checkpoint resistance.
Combination Immunotherapy Strategies
Developed preclinical rationale for targeting Treg-mediated suppression in combination with PD-1/PD-L1 blockade, advancing translational approaches to overcome non-inflamed tumor phenotypes.
Representative Works 代表性著作
Antitumor Effects of IL-35-Producing T Regulatory Cells
Nature Medicine (2023)
Demonstrated that IL-35 secreted by tumor-infiltrating Tregs suppresses anti-tumor immune responses and that targeting this axis enhances immunotherapy efficacy.
Intratumoral Regulatory T Cells Upregulate Immunosuppressive Molecules in an Exhaustion-Independent Manner
JCI Insight (2021)
Revealed that tumor-infiltrating Tregs maintain suppressive function through mechanisms distinct from conventional T cell exhaustion.
Characterization of Regulatory T Cells in Tumor-Draining Lymph Nodes from Patients with Solid Tumors
Cancer Immunology Research (2020)
Profiled Treg phenotypes and function in lymph nodes of cancer patients, linking regional immunosuppression to systemic checkpoint resistance.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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