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Translational Medicine / 转化医学Intestinal Stem Cell Evolution, Clonal Dynamics

Trevor Graham

PhD

🏢Barts Cancer Institute, Queen Mary University of London🌐UK

Professor of Genomics and Evolution

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👥Biography 个人简介

Trevor Graham has revealed the evolutionary dynamics of intestinal stem cells that underpin colorectal cancer initiation. His work using lineage tracing and single-cell genomics demonstrated how mutations accumulate in intestinal crypts through neutral drift and how field cancerization establishes pre-malignant clones. He has developed computational methods for reconstructing the evolutionary history of colorectal tumors from their genetic diversity.

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🧪Research Fields 研究领域

intestinal stem cell evolution
crypt dynamics
colorectal cancer initiation
somatic mutation accumulation
field cancerization

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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