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Translational Medicine / 转化医学Anti-Angiogenic Therapy, Cabozantinib Multi-Kinase

Toni Choueiri

MD

🏢Dana-Farber Cancer Institute🌐USA

Director, Lank Center for Genitourinary Oncology

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👥Biography 个人简介

Dr. Toni Choueiri is a GU oncologist at Dana-Farber and a leading expert in multi-target anti-angiogenic tyrosine kinase inhibitors. He has led pivotal trials of cabozantinib in renal cell carcinoma including METEOR and CABOSUN, exploiting its co-inhibition of VEGFR2, MET, and AXL to overcome adaptive resistance pathways that limit VEGFR-selective agents. His work on combining cabozantinib with nivolumab in CheckMate-9ER has established dual anti-angiogenic plus checkpoint blockade as a first-line RCC standard.

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🧪Research Fields 研究领域

cabozantinib VEGFR MET AXL inhibitor
cabozantinib renal cell carcinoma
cabozantinib thyroid cancer
multi-kinase anti-angiogenic therapy
VEGFR2 MET AXL triple target

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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