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Translational Medicine / 转化医学Base Excision Repair, Nobel Laureate

Tomas Lindahl

MD PhD

🏢The Francis Crick Institute🌐UK

Emeritus Group Leader

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Key Contributions

👥Biography 个人简介

Tomas Lindahl shared the 2015 Nobel Prize for discovering base excision repair (BER) — the cellular mechanism for correcting damaged DNA bases including those resulting from hydrolysis, oxidation, and alkylation. His discovery that DNA is inherently unstable and requires continuous repair, and his characterization of BER enzymes including DNA glycosylases and PARP1's role in BER, has been foundational to understanding cancer mutations and to the development of PARP inhibitor cancer therapy.

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🧪Research Fields 研究领域

base excision repair
Nobel Prize 2015
DNA instability
PARP1 repair
DNA glycosylases

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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