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Translational Medicine / 转化医学Cancer Drug Discovery, Chemical Genomics

Todd Golub

MD

🏢Broad Institute of MIT and Harvard🌐USA

Director, Cancer Program

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👥Biography 个人简介

Todd Golub is a cancer biologist and physician-scientist who has transformed cancer drug discovery through genomic approaches, including the development of the PRISM high-throughput drug sensitivity profiling platform that screens hundreds of compounds across thousands of cancer cell lines. His work has identified unexpected drug sensitivities and rational combination hypotheses including IO+targeted therapy combinations. He is a founding contributor to the Cancer Cell Line Encyclopedia (CCLE) and has pioneered the use of small molecule repurposing for cancer combination regimens.

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🧪Research Fields 研究领域

cancer drug discovery genomics
PRISM cancer drug sensitivity profiling
drug repurposing cancer
chemical genomics cancer vulnerabilities
compound screening oncology therapeutic discovery

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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