Tobias Else
托比亚斯·埃尔斯
MD
Associate Professor of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes内科学副教授，代谢内分泌与糖尿病科
👥Biography 个人简介
Tobias Else at the University of Michigan leads research on the genetic basis of adrenocortical carcinoma, focusing on hereditary predisposition syndromes including Li-Fraumeni syndrome and Lynch syndrome. He has advanced understanding of ACC molecular subtypes and directed national ACC research programs.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Hereditary ACC Syndromes
Characterized the frequency and clinical presentation of hereditary ACC including TP53 (Li-Fraumeni), Lynch syndrome, MEN1, and KCNJ5 mutations, establishing genetic testing guidelines.
ACC Molecular Subtype Classification
Contributed to defining the transcriptomic and epigenomic subtypes of ACC with distinct prognosis, supporting precision oncology approaches in this rare malignancy.
ACC Surveillance Programs
Developed evidence-based surveillance protocols for at-risk hereditary syndrome carriers, enabling early ACC detection in asymptomatic mutation carriers.
Representative Works 代表性著作
Adrenocortical Carcinoma: An Update on Pathogenesis, Diagnosis, and Treatment
Endocrine Reviews (2014)
Comprehensive review integrating molecular pathogenesis, clinical diagnosis, and multimodal treatment of adrenocortical carcinoma.
Hereditary and Familial Adrenocortical Tumors
Hormone and Cancer (2013)
Systematic analysis of hereditary syndromes predisposing to adrenocortical tumors and recommended genetic testing approaches.
Germline TP53 Mutations in Adrenocortical Cancer Patients: Clinical Implications and Functional Characterization
European Journal of Endocrinology (2015)
Defined TP53 mutation prevalence in adult ACC and implications for Li-Fraumeni syndrome surveillance and family counseling.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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