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Translational Medicine / 转化医学ACC Genomics, Hereditary Syndromes

Tobias Else

MD

🏢University of Michigan Medical School🌐USA

Associate Professor of Internal Medicine

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👥Biography 个人简介

Tobias Else is a physician-scientist studying the molecular genetics of adrenocortical carcinoma, including characterization of somatic driver alterations in ATRX, CDK4/CDKN2A, and ZNRF3 that define distinct ACC molecular subtypes with different prognoses. His group has investigated the adrenal tumor microenvironment and analyzed PD-L1 expression and immune infiltration patterns as predictors of immunotherapy response. He also studies hereditary ACC risk, including Li-Fraumeni syndrome surveillance and other rare germline predispositions.

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🧪Research Fields 研究领域

ACC somatic genomics ATRX CDK4
hereditary ACC TP53 germline
adrenal tumor microenvironment
ACC immune checkpoint PD-L1
adrenal incidentaloma malignancy risk

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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