Timothy Yap
蒂莫西·叶
MBBS, PhD, FRCP
Professor and Vice President of Clinical Development; Medical Director, Institute for Applied Cancer Science临床开发副总裁；应用癌症科学研究所医学主任
👥Biography 个人简介
Timothy Yap leads early-phase clinical development of DNA damage response (DDR) inhibitors at MD Anderson. He specializes in PARP, ATR, WEE1, and POLQ inhibitor trials, pioneering synthetic lethality strategies and rational combination approaches to improve efficacy and overcome resistance.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
ATR Inhibitor Development
Led early-phase trials of ATR inhibitors (ceralasertib, elimusertib), defining optimal dosing, safety, and biomarker strategies for DDR-targeted combinations in solid tumors.
Synthetic Lethality Combinations
Developed clinical combination strategies exploiting synthetic lethality beyond BRCA, expanding DDR inhibitor utility across multiple tumor types with defined genomic vulnerabilities.
Biomarker-Driven Trial Design
Integrated functional pharmacodynamic biomarkers (gamma-H2AX, RAD51) into early-phase trials to demonstrate target engagement and guide dose optimization.
Representative Works 代表性著作
Phase I Trial of the PARP Inhibitor Olaparib Combined with the ATR Inhibitor Ceralasertib
Cancer Discovery (2022)
Demonstrated safety and efficacy of PARP/ATR inhibitor combination, establishing a platform for DDR combination trials.
First-in-Human Phase I Trial of the WEE1 Inhibitor Adavosertib
Journal of Clinical Oncology (2020)
Defined recommended phase II dose and identified predictive biomarkers for WEE1 inhibition in advanced solid tumors.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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