Funda Meric-Bernstam
芳达·梅里奇-伯恩斯塔姆
MD
Professor and Chair, Investigational Cancer Therapeutics; Director, Institute for Applied Cancer Science研究性癌症治疗学系主任；应用癌症科学研究所所长
👥Biography 个人简介
Funda Meric-Bernstam is a world leader in precision oncology clinical trial design, directing the largest phase I program in the US. She pioneered basket and umbrella trial frameworks, led FGFR and HER2 inhibitor development programs, and advances genotype-matched therapy strategies across solid tumors.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Basket and Umbrella Trial Innovation
Designed and led major basket and umbrella trial programs (e.g., IMPACT, TREAT ALL) matching patients to therapies by molecular alteration regardless of tumor histology.
Zanidatamab and HER2-Targeted Trials
Principal investigator for multiple HER2-directed bispecific antibody and ADC programs, expanding precision HER2 targeting beyond traditional indications.
FGFR Inhibitor Development
Led early-phase clinical trials of FGFR inhibitors (infigratinib, futibatinib) in FGFR-altered cancers, defining biomarker-selected patient populations and response strategies.
Representative Works 代表性著作
Pertuzumab Plus Trastuzumab in HER2-Amplified Cancers Beyond Breast Cancer
Nature Medicine (2019)
Basket trial demonstrating HER2 dual blockade activity in non-breast HER2-amplified cancers, supporting tumor-agnostic targeting.
Neratinib in HER2-Mutant, Non-Amplified Cancers: The SUMMIT Trial
Cancer Discovery (2020)
Demonstrated neratinib efficacy across HER2-mutated solid tumors beyond breast cancer in a histology-agnostic basket trial.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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