Alison Schram
艾莉森·施拉姆
MD
Medical Oncologist; Early Drug Development Service肿瘤内科医生；早期药物开发部
👥Biography 个人简介
Alison Schram is a leading investigator in early-phase trials targeting HER2 alterations across tumor types. She has led pivotal basket trials of HER2-directed ADCs and bispecific antibodies, advancing tumor-agnostic approvals and broadening HER2-targeted therapy beyond breast cancer.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
HER2-Directed Basket Trials
Led the DESTINY-PanTumor02 and related basket trials establishing trastuzumab deruxtecan efficacy across HER2-expressing solid tumors, enabling tumor-agnostic FDA approval.
Zanidatamab Development
Served as principal investigator in early-phase studies of zanidatamab (bispecific HER2 antibody), defining clinical activity in biliary tract and other HER2-amplified cancers.
Novel ADC Clinical Development
Contributed to early-phase development of multiple HER2-directed ADCs, characterizing safety profiles, optimal dosing, and predictive biomarkers across diverse tumor histologies.
Representative Works 代表性著作
Trastuzumab Deruxtecan in HER2-Expressing Solid Tumors (DESTINY-PanTumor02)
New England Journal of Medicine (2023)
Demonstrated broad efficacy of T-DXd in HER2-expressing tumors, supporting histology-agnostic regulatory approval.
Zanidatamab in HER2-Amplified Biliary Tract Cancer
Lancet Oncology (2023)
Phase II trial establishing zanidatamab as an active agent in HER2-amplified biliary tract cancers with durable responses.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Johann de Bono
Institute of Cancer Research / Royal Marsden Hospital
Timothy Yap
The University of Texas MD Anderson Cancer Center
Anthony Tolcher
NEXT Oncology
Funda Meric-Bernstam
The University of Texas MD Anderson Cancer Center
关注 艾莉森·施拉姆 的研究动态
Follow Alison Schram's research updates
留下邮箱，当我们发布与 Alison Schram（Memorial Sloan Kettering Cancer Center）相关的新研究或访谈时，我们会通知你。
Explore More Experts
Discover the researchers shaping the future of cancer treatment