Anthony Tolcher
安东尼·托尔彻
MD, FRCPC
Chief Medical Officer and Co-Founder首席医疗官兼联合创始人
👥Biography 个人简介
Anthony Tolcher is a pioneer in early-phase oncology clinical trials with over 25 years conducting first-in-human studies. He co-founded NEXT Oncology to accelerate novel agent development, specializing in antibody-drug conjugates, bispecific antibodies, and targeted payload strategies across solid tumors.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
First-in-Human Trial Expertise
Conducted over 300 first-in-human and phase I trials, developing methodologies for dose escalation, PK/PD assessment, and early efficacy signal detection for novel oncology agents.
Antibody-Drug Conjugate Development
Played a key role in early clinical development of multiple ADCs, establishing linker-payload optimization strategies and managing on-target and off-target toxicity profiles.
NEXT Oncology Platform
Built a dedicated early-phase trial infrastructure enabling rapid startup, real-time biomarker analysis, and seamless industry-academic collaboration for novel compound testing.
Representative Works 代表性著作
Safety and Activity of Anti-PD-L1 Antibody MPDL3280A in Patients with Metastatic NSCLC
New England Journal of Medicine (2015)
Early phase trial demonstrating efficacy of atezolizumab in NSCLC, contributing to PD-L1 checkpoint inhibitor development.
Phase I Study of AMG 479 (Ganitumab) in Advanced Solid Tumors
Clinical Cancer Research (2012)
Defined safety, PK, and pharmacodynamic profile of IGF-1R antibody in early-phase solid tumor patients.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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Institute of Cancer Research / Royal Marsden Hospital
Timothy Yap
The University of Texas MD Anderson Cancer Center
Alison Schram
Memorial Sloan Kettering Cancer Center
Funda Meric-Bernstam
The University of Texas MD Anderson Cancer Center
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