Tim Wang

Tim Wang developed high-fidelity CRISPR fitness screening methods that improved the accuracy of genome-wide loss-of-function screens in cancer cells, enabling precise identification of genes essential for cancer cell proliferation and survival. His computational frameworks for analyzing CRISPR screen data have become standard tools for distinguishing true cancer dependencies from technical artifacts. He has applied CRISPR fitness screens to map synthetic lethal interactions, identifying gene pairs where simultaneous loss is lethal to cancer cells while individual loss is tolerated, revealing new therapeutic vulnerabilities. His work has been central to building comprehensive maps of cancer cell dependencies that inform drug target prioritization.