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Translational Medicine / 转化医学Hedgehog Signaling, Medulloblastoma

Thomas Bhatt

MD

🏢The Hospital for Sick Children, Toronto🌐Canada

Associate Professor of Pediatric Neuro-Oncology

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Key Contributions

👥Biography 个人简介

Thomas Bhatt specializes in the SHH subgroup of medulloblastoma, which is driven by Hedgehog pathway activation through PTCH1 mutations or SMO mutations. His research has characterized the molecular heterogeneity within SHH medulloblastoma and identified subgroups with distinct prognoses and therapeutic vulnerabilities. He has evaluated SMO inhibitor therapy in pediatric SHH medulloblastoma and examined mechanisms of primary resistance in infants. His translational work guides the design of molecularly informed treatment protocols for SHH medulloblastoma patients.

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🧪Research Fields 研究领域

medulloblastoma
Hedgehog subgroup
pediatric brain tumors
SMO inhibitors
molecular subgrouping

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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