Theresa A. Guise

Theresa Guise is a pioneering bone metastasis biologist who discovered that PTHrP (parathyroid hormone-related protein) produced by breast cancer cells is a key mediator of osteolytic bone destruction and pathological fractures. Her mechanistic studies of the PTHrP/RANKL axis in bone metastasis have guided therapeutic strategies. She has investigated how targeting PTHrP production or action can reduce skeletal-related events in preclinical models. Her research program also examines TGF-beta signaling in the bone microenvironment as a driver of cancer growth and bone destruction.