Tetsuya Mitsudomi
光冢哲也
MD, PhD
Professor and Chair, Division of Thoracic Surgery; Director, Thoracic Oncology Program胸外科主任教授；胸部肿瘤项目主任
👥Biography 个人简介
Japan's foremost thoracic surgical oncologist and EGFR research pioneer. Led the IMPACT trial evaluating gefitinib as adjuvant therapy in Japanese EGFR-mutant NSCLC after complete resection, and established foundational EGFR mutation detection methodologies widely adopted in Asia.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
IMPACT Trial - Adjuvant Gefitinib
Led the IMPACT phase III trial comparing adjuvant gefitinib versus cisplatin/vinorelbine in Japanese EGFR-mutant resected NSCLC, providing key data on EGFR TKI adjuvant benefit that informed subsequent global ADAURA design.
EGFR Mutation Detection Methods
Pioneered highly sensitive EGFR mutation detection technologies applicable to surgical specimens and liquid biopsies, establishing methodological foundations adopted across Japanese and Asian oncology centers.
Representative Works 代表性著作
Gefitinib versus Cisplatin plus Vinorelbine as Adjuvant Setting in Patients with EGFR-Mutated Completely Resected Stage II-IIIA NSCLC (IMPACT, WJOG 6410L)
Journal of Clinical Oncology (2021)
Phase III IMPACT trial demonstrating gefitinib DFS benefit versus chemotherapy in EGFR-mutant resected NSCLC, contributing to adjuvant TKI evidence base.
Mutations of the Epidermal Growth Factor Receptor Gene and Related Genes as Determinants of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors Sensitivity in Lung Cancer
Cancer Science (2010)
Foundational review establishing EGFR mutation landscape and its deterministic role in TKI sensitivity, widely cited in Japanese thoracic oncology.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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