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Translational Medicine / 转化医学Cancer Cachexia, Myostatin Activin Pathway

Teresa Zimmers

PhD

🏢Indiana University School of Medicine🌐USA

Professor, Department of Surgery

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Key Contributions

👥Biography 个人简介

Teresa Zimmers has extensively characterized the role of TGF-beta superfamily ligands including myostatin, activin A, and GDF11 in cancer-associated muscle wasting. Her research demonstrated that tumor-derived activin A causes profound muscle wasting in animal models and has provided mechanistic rationale for ActRII pathway blockade in cachexia. She has contributed to translation of these findings into anti-myostatin and anti-activin clinical trial programs.

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🧪Research Fields 研究领域

myostatin cancer cachexia
activin receptor II signaling muscle
GDF11 GDF15 muscle wasting cancer
ActRII inhibitors cachexia
muscle atrophy molecular pathways cancer

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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