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Translational Medicine / 转化医学Bifunctional Antibody Engineering

Ali Tehrani

PhD

🏢Zymeworks🌐Canada

Co-Founder and Former CEO

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👥Biography 个人简介

Ali Tehrani co-founded Zymeworks and developed the Azymetric bispecific antibody platform, which uses computational protein engineering to enable efficient heterodimerization of bispecific antibody heavy chains with high purity and manufacturability. His platform has been widely licensed by pharmaceutical companies for developing bifunctional antibody therapeutics across oncology. His work demonstrated that computational approaches to protein engineering can solve the manufacturability challenges that have historically limited bispecific antibody development.

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🧪Research Fields 研究领域

Azymetric bispecific platform
Bispecific antibody manufacturability
Protein engineering computational
Antibody-drug conjugate bispecifics
Multispecific therapeutic design

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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