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Translational Medicine / 转化医学Milestone, PD-1 Discovery

Tasuku Honjo

MD, PhD

🏢Kyoto University🌐Japan

Distinguished Professor; Nobel Laureate

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👥Biography 个人简介

Tasuku Honjo is a Nobel Prize laureate (2018) who discovered PD-1 (programmed death-1) and demonstrated its role as a key checkpoint in suppressing immune responses, including anti-tumor immunity. His laboratory's work showing that PD-1 blockade could treat cancer established the scientific foundation for pembrolizumab, nivolumab, and the entire class of anti-PD-1/PD-L1 therapies now transforming oncology across virtually every cancer type.

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🧪Research Fields 研究领域

PD-1 discovery
programmed death 1
PD-1 PD-L1 checkpoint
cancer immunotherapy Nobel Prize
immune checkpoint biology

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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