Takayuki Yoshino
吉野孝之
MD, PhD
Head, Department of Gastrointestinal Oncology消化道肿瘤科主任
👥Biography 个人简介
Takayuki Yoshino leads the SCRUM-Japan pan-cancer genomic screening program and is Asia's foremost authority on CRC molecular precision oncology. He spearheaded ctDNA rechallenge trials for EGFR-resistant CRC and built Japan's infrastructure for nationwide genomics-driven treatment matching in CRC.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
SCRUM-Japan Genomic Screening
Founded and directs SCRUM-Japan, the world's largest cancer genome screening registry, enabling rapid accrual to genomically matched CRC trials across Asia.
EGFR Rechallenge ctDNA Trials
Led REMARC and CHRONOS-J trials demonstrating clinical validity of ctDNA-guided anti-EGFR rechallenge in Japanese and Asian CRC patients after acquired resistance.
Representative Works 代表性著作
Circulating tumor DNA as a predictive biomarker for anti-EGFR rechallenge therapy in colorectal cancer (CHRONOS trial)
Nature Medicine (2022)
Validated ctDNA-guided cetuximab rechallenge in RAS/BRAF wild-type metastatic CRC after prior anti-EGFR treatment.
SCRUM-Japan GOZILA study: nationwide genomic screening for precision oncology in CRC
Nature Communications (2021)
Described Japan's nationwide ctDNA genomic screening infrastructure enabling precision-matched treatment in CRC.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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