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Translational Medicine / 转化医学Gynecologic Cancer IO-PARP Combinations

Susana Banerjee

MB BChir PhD

🏢Royal Marsden Hospital🌐UK

Consultant Medical Oncologist

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👥Biography 个人简介

Susana Banerjee at Royal Marsden has contributed to gynecologic oncology clinical research, including trials combining PARP inhibitors with checkpoint immunotherapy. The DUO-O trial and other trials investigating IO-PARP combinations exploit the hypothesis that PARP inhibitor-induced DNA damage may increase tumor mutational burden and neoantigen expression, potentially enhancing checkpoint immunotherapy response — an area of active investigation across gynecologic and other cancers.

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🧪Research Fields 研究领域

olaparib pembrolizumab ovarian cancer
PARP inhibitor IO combination GI gynecologic
DUO-O trial IO PARP combination
gynecologic cancer clinical trials UK
BRCA ovarian IO PARP synergy

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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