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Translational Medicine / 转化医学Proteostasis, HSP90 Capacitor (Historical)
Susan Lindquist
PhD
🏢Whitehead Institute / MIT🌐USA
Member, Whitehead Institute (Historical)
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Key Papers
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Key Contributions
👥Biography 个人简介
Susan Lindquist (deceased 2016) was a transformative figure who established HSP90 as a buffer of phenotypic variation and a cancer dependency. Her work showed that HSP90 stabilizes mutant oncoproteins and enables tumor evolution. Her legacy underpins ongoing HSP90-targeted therapy development.
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🧪Research Fields 研究领域
HSP90
proteostasis
evolutionary capacitor
protein folding
cancer chaperones
🎓Key Contributions 主要贡献
Representative Works 代表性著作
📄Data Sources 数据来源
Last updated: 2026-04-01 | All information from publicly available academic sources
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