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Translational Medicine / 转化医学RAD51C/D, BRCA-Related Gene Syndromes

Susan Domchek

MD

🏢University of Pennsylvania🌐USA

Executive Director, Basser Center for BRCA

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👥Biography 个人简介

Susan Domchek at the Basser Center for BRCA is a leading expert in hereditary breast and ovarian cancer syndromes, with particular expertise in RAD51C and RAD51D germline variants that confer elevated ovarian cancer risk. She has studied the cancer risks associated with these variants and the role of risk-reducing salpingo-oophorectomy. Her work has also explored PARP inhibitor sensitivity in RAD51-mutated cancers beyond BRCA.

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🧪Research Fields 研究领域

RAD51C RAD51D ovarian risk
BRCA-related gene surveillance
risk-reducing salpingo-oophorectomy
hereditary ovarian cancer
PARP inhibitors germline RAD51

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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