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Translational Medicine / 转化医学Clinical Trial Innovation

Sumithra Mandrekar

苏米特拉·曼德雷卡尔

PhD

🏢Mayo Clinic(梅奥诊所)🌐USA

Professor of Biostatistics; Co-Chair, SWOG Cancer Research Network Statistics and Data Management Center生物统计学教授;SWOG癌症研究网络统计与数据管理中心联合主席

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Sumithra Mandrekar, PhD is a premier oncology biostatistician at Mayo Clinic and statistical co-leader of the SWOG Cancer Research Network. She is internationally recognized for developing and applying adaptive clinical trial designs in cooperative group oncology trials, particularly in lung cancer and precision oncology studies.

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🧪Research Fields 研究领域

Oncology Clinical Trial Design肿瘤学临床试验设计
SWOG Network StatisticsSWOG网络统计学
Adaptive Designs适应性试验设计
Biomarker-Driven Trials生物标志物驱动试验
Lung Cancer Clinical Trials肺癌临床试验

🎓Key Contributions 主要贡献

Adaptive Designs in Cooperative Group Oncology Trials

Led the statistical design and implementation of adaptive clinical trials within SWOG and NCTN cooperative group frameworks, advancing the adoption of innovative designs in large-scale national oncology trials.

Biomarker-Driven Lung Cancer Trial Design

Developed innovative statistical methodologies for biomarker-enriched lung cancer trials, including adaptive enrichment and selection designs that improve efficiency of precision oncology studies.

Representative Works 代表性著作

[1]

Randomized Phase II Adaptive Trial Design in Lung Cancer: Lessons from SWOG

Journal of Thoracic Oncology (2019)

Landmark paper reporting operational and statistical lessons from implementing adaptive designs within SWOG cooperative group lung cancer clinical trials.

[2]

Statistical Considerations for Biomarker-Driven Adaptive Clinical Trials in Oncology

Clinical Cancer Research (2023)

Comprehensive framework for integrating biomarker selection with adaptive design elements in national cooperative group precision oncology trials.

🏆Awards & Recognition 奖项与荣誉

🏆Mayo Clinic Distinguished Investigator Award
🏆American Statistical Association Fellow
🏆SWOG Outstanding Scientific Achievement Award
🏆NCI Cancer Trials Support Unit Excellence in Biostatistics Award

📄Data Sources 数据来源

Last updated: 2026-01-15 | All information from publicly available academic sources

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