Steven A. Rosenberg
M.D., Ph.D.
Chief, Surgery Branch
👥Biography 个人简介
Steven Rosenberg is widely regarded as the father of modern cancer immunotherapy. His laboratory at the National Cancer Institute pioneered the use of tumor-infiltrating lymphocytes (TILs) for cancer treatment, demonstrating durable complete responses in metastatic melanoma. Rosenberg's work laid the foundation for all adoptive cell therapies including CAR-T cells, and he continues to advance personalized cancer immunotherapy approaches.
Steven Rosenberg被广泛认为是现代癌症免疫治疗之父。他在美国国家癌症研究所的实验室开创了使用肿瘤浸润淋巴细胞(TIL)治疗癌症的方法,在转移性黑色素瘤中展示了持久的完全缓解。Rosenberg的工作为包括CAR-T细胞在内的所有过继细胞治疗奠定了基础,他继续推进个性化癌症免疫治疗方法。
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
TIL Therapy
Developed tumor-infiltrating lymphocyte therapy achieving durable remissions in melanoma.
IL-2 Immunotherapy
Led development of high-dose IL-2 therapy, first FDA-approved cancer immunotherapy.
Neoantigen-Targeted Therapy
Pioneered identification and targeting of patient-specific tumor neoantigens.
Representative Works 代表性著作
Use of Tumor-Infiltrating Lymphocytes and Interleukin-2 in the Immunotherapy of Patients with Metastatic Melanoma
New England Journal of Medicine (1988)
Landmark paper establishing TIL therapy for melanoma.
Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy
Clinical Cancer Research (2011)
Long-term follow-up demonstrating curative potential of TIL therapy.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-03-04 | All information from publicly available academic sources
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