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Cell Therapy / 细胞治疗TIL

Steven A. Rosenberg

M.D., Ph.D.

🏢National Cancer Institute🌐USA

Chief, Surgery Branch

2
Key Papers
3
Awards
3
Key Contributions

👥Biography 个人简介

Steven Rosenberg is widely regarded as the father of modern cancer immunotherapy. His laboratory at the National Cancer Institute pioneered the use of tumor-infiltrating lymphocytes (TILs) for cancer treatment, demonstrating durable complete responses in metastatic melanoma. Rosenberg's work laid the foundation for all adoptive cell therapies including CAR-T cells, and he continues to advance personalized cancer immunotherapy approaches.

Steven Rosenberg被广泛认为是现代癌症免疫治疗之父。他在美国国家癌症研究所的实验室开创了使用肿瘤浸润淋巴细胞(TIL)治疗癌症的方法,在转移性黑色素瘤中展示了持久的完全缓解。Rosenberg的工作为包括CAR-T细胞在内的所有过继细胞治疗奠定了基础,他继续推进个性化癌症免疫治疗方法。

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🧪Research Fields 研究领域

Tumor-Infiltrating Lymphocytes肿瘤浸润淋巴细胞
Cancer Immunotherapy癌症免疫治疗
Adoptive Cell Transfer过继细胞转移

🎓Key Contributions 主要贡献

TIL Therapy

Developed tumor-infiltrating lymphocyte therapy achieving durable remissions in melanoma.

IL-2 Immunotherapy

Led development of high-dose IL-2 therapy, first FDA-approved cancer immunotherapy.

Neoantigen-Targeted Therapy

Pioneered identification and targeting of patient-specific tumor neoantigens.

Representative Works 代表性著作

[1]

Use of Tumor-Infiltrating Lymphocytes and Interleukin-2 in the Immunotherapy of Patients with Metastatic Melanoma

New England Journal of Medicine (1988)

Landmark paper establishing TIL therapy for melanoma.

[2]

Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy

Clinical Cancer Research (2011)

Long-term follow-up demonstrating curative potential of TIL therapy.

🏆Awards & Recognition 奖项与荣誉

🏆National Medal of Technology and Innovation (2024)
🏆Breakthrough Prize in Life Sciences (2023)
🏆Albany Medical Center Prize (2019)

📄Data Sources 数据来源

Last updated: 2026-03-04 | All information from publicly available academic sources

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