Michel Sadelain

Michel Sadelain is a pioneer in T cell engineering who developed foundational concepts for CAR-T cell therapy, including the incorporation of costimulatory domains (CD28, 4-1BB) that dramatically improved CAR-T cell persistence and efficacy. His systematic approach to CAR design established principles now used across the field. Sadelain's work has contributed to multiple FDA-approved CAR-T products and continues to advance next-generation cellular immunotherapies.

Michel Sadelain是T细胞工程的先驱，开发了CAR-T细胞治疗的基础概念，包括纳入共刺激结构域（CD28、4-1BB），显著提高了CAR-T细胞的持久性和效力。他对CAR设计的系统方法建立了现在全领域使用的原则。Sadelain的工作为多个FDA批准的CAR-T产品做出了贡献，并继续推进下一代细胞免疫治疗。