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Cell Therapy / 细胞治疗CAR-NK

Dan S. Kaufman

M.D., Ph.D.

🏢University of California San Diego🌐USA

Professor, Department of Medicine

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Key Papers
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Key Contributions

👥Biography 个人简介

Dan Kaufman is a leader in developing induced pluripotent stem cell (iPSC)-derived natural killer cells for cancer immunotherapy. His laboratory has established robust methods for differentiating iPSCs into functional NK cells that can be genetically engineered with CARs and other enhancements. This approach enables unlimited production of standardized NK cell products for off-the-shelf cancer therapy.

Dan Kaufman是开发诱导多能干细胞(iPSC)衍生的自然杀伤细胞用于癌症免疫治疗的领导者。他的实验室建立了将iPSC分化为功能性NK细胞的稳健方法,这些细胞可以通过CAR和其他增强进行基因工程改造。这种方法能够无限生产标准化的NK细胞产品用于现成的癌症治疗。

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🧪Research Fields 研究领域

iPSC-derived NK CellsiPSC衍生NK细胞
Stem Cell Biology干细胞生物学
Cancer Immunotherapy癌症免疫治疗

🎓Key Contributions 主要贡献

iPSC-NK Differentiation

Developed scalable protocols for generating functional NK cells from human pluripotent stem cells.

NK Cell Engineering

Pioneered genetic modification of iPSC-NK cells with CARs and cytokine enhancements.

Representative Works 代表性著作

[1]

Human embryonic stem cell-derived NK cells acquire functional receptors and cytolytic activity

Journal of Immunology (2005)

First demonstration of functional NK cell derivation from human pluripotent stem cells.

📄Data Sources 数据来源

Last updated: 2026-03-04 | All information from publicly available academic sources

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