Katy Rezvani
M.D., Ph.D.
Professor, Department of Stem Cell Transplantation
👥Biography 个人简介
Katy Rezvani is a pioneer in developing CAR-engineered natural killer (NK) cells for cancer therapy. Her laboratory has advanced cord blood-derived CAR-NK cells as an off-the-shelf cellular therapy, demonstrating remarkable safety and efficacy in early clinical trials. Rezvani's work addresses key limitations of CAR-T cells, including the potential for allogeneic use without severe graft-versus-host disease.
Katy Rezvani是开发CAR工程化自然杀伤(NK)细胞用于癌症治疗的先驱。她的实验室推进了脐带血来源的CAR-NK细胞作为现成的细胞治疗,在早期临床试验中展示了显著的安全性和有效性。Rezvani的工作解决了CAR-T细胞的关键局限性,包括在不发生严重移植物抗宿主病的情况下进行异基因使用的潜力。
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
CAR-NK Development
Developed cord blood-derived CAR-NK cells with enhanced persistence and anti-tumor activity.
Clinical Translation
Led first-in-human trials of CAR-NK cells showing high response rates with minimal toxicity.
Representative Works 代表性著作
Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors
New England Journal of Medicine (2020)
Landmark trial demonstrating CAR-NK cell safety and efficacy in lymphoma.
📄Data Sources 数据来源
Last updated: 2026-03-04 | All information from publicly available academic sources
Related Experts 相关专家
Carl H. June
University of Pennsylvania
Michel Sadelain
Memorial Sloan Kettering Cancer Center
Crystal L. Mackall
Stanford University
Dan S. Kaufman
University of California San Diego
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