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Cell Therapy / 细胞治疗CAR-NK

Katy Rezvani

M.D., Ph.D.

🏢MD Anderson Cancer Center🌐USA

Professor, Department of Stem Cell Transplantation

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Key Papers
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Key Contributions

👥Biography 个人简介

Katy Rezvani is a pioneer in developing CAR-engineered natural killer (NK) cells for cancer therapy. Her laboratory has advanced cord blood-derived CAR-NK cells as an off-the-shelf cellular therapy, demonstrating remarkable safety and efficacy in early clinical trials. Rezvani's work addresses key limitations of CAR-T cells, including the potential for allogeneic use without severe graft-versus-host disease.

Katy Rezvani是开发CAR工程化自然杀伤(NK)细胞用于癌症治疗的先驱。她的实验室推进了脐带血来源的CAR-NK细胞作为现成的细胞治疗,在早期临床试验中展示了显著的安全性和有效性。Rezvani的工作解决了CAR-T细胞的关键局限性,包括在不发生严重移植物抗宿主病的情况下进行异基因使用的潜力。

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🧪Research Fields 研究领域

CAR-NK CellsCAR-NK细胞
Natural Killer Cell Biology自然杀伤细胞生物学
Cancer Immunotherapy癌症免疫治疗

🎓Key Contributions 主要贡献

CAR-NK Development

Developed cord blood-derived CAR-NK cells with enhanced persistence and anti-tumor activity.

Clinical Translation

Led first-in-human trials of CAR-NK cells showing high response rates with minimal toxicity.

Representative Works 代表性著作

[1]

Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors

New England Journal of Medicine (2020)

Landmark trial demonstrating CAR-NK cell safety and efficacy in lymphoma.

📄Data Sources 数据来源

Last updated: 2026-03-04 | All information from publicly available academic sources

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