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Translational Medicine / 转化医学DLBCL Tisagenlecleucel, Bispecific Antibodies

Stephen Schuster

MD

🏢University of Pennsylvania, Abramson Cancer Center🌐USA

Professor of Medicine; Director, Lymphoma Program

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👥Biography 个人简介

Stephen Schuster co-led the JULIET trial establishing tisagenlecleucel as an effective CAR-T therapy for relapsed/refractory DLBCL, building on the foundational work at Penn on adoptive cell therapy. He has subsequently investigated epcoritamab (anti-CD3xCD20 bispecific) in relapsed DLBCL and studied sequencing of CAR-T and bispecific therapies. His research also addresses the immune biology of DLBCL tumor microenvironment and how it influences CAR-T engraftment and persistence. He remains active in developing novel lymphoma clinical trials at Penn.

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🧪Research Fields 研究领域

tisagenlecleucel DLBCL JULIET trial
DLBCL CD19 CAR-T Penn approach
epcoritamab DLBCL bispecific
DLBCL salvage strategies
DLBCL overall survival CAR-T

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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