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Translational Medicine / 转化医学Biomarkers

Stephen B. Baylin

M.D.

🏢Johns Hopkins University🌐USA

Virginia and D.K. Ludwig Professor of Oncology

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Key Papers
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Key Contributions

👥Biography 个人简介

Stephen Baylin is a pioneer in cancer epigenetics who discovered that DNA methylation silences tumor suppressor genes in cancer. His work has led to FDA-approved epigenetic therapies and continues to inform understanding of how epigenetic changes drive cancer development and can be targeted therapeutically.

Stephen Baylin是癌症表观遗传学的先驱,发现了DNA甲基化在癌症中沉默肿瘤抑制基因。他的工作导致了FDA批准的表观遗传疗法,并继续为理解表观遗传变化如何驱动癌症发展以及如何靶向治疗提供信息。

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🧪Research Fields 研究领域

Cancer Epigenetics癌症表观遗传学
DNA MethylationDNA甲基化
Tumor Suppressors肿瘤抑制因子

🎓Key Contributions 主要贡献

DNA Methylation

Characterized promoter hypermethylation as cancer hallmark.

Epigenetic Therapy

Foundational work leading to DNMT inhibitor approvals.

Representative Works 代表性著作

[1]

Aberrant CpG island methylation in cancer

Nature Reviews Genetics (2002)

Seminal review of DNA methylation in cancer.

📄Data Sources 数据来源

Last updated: 2026-03-05 | All information from publicly available academic sources

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