Stephan Stilgenbauer
斯蒂凡·斯蒂根鲍尔
MD
Professor of Internal Medicine; Director, Department III (Hematology, Oncology, Palliative Medicine)内科学教授兼第三科（血液肿瘤姑息医学）主任
👥Biography 个人简介
Prof. Stephan Stilgenbauer is a world authority on high-risk CLL biology and therapy, particularly del(17p)/TP53-mutated disease. His pivotal M13-982 venetoclax monotherapy trial in del(17p) CLL led directly to the FDA approval of venetoclax in this difficult-to-treat population.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Venetoclax in Del(17p) CLL
Led the M13-982 phase 2 trial demonstrating high response rates and durable remissions with venetoclax monotherapy in del(17p)/TP53-mutated CLL, directly supporting FDA approval and changing standard of care for this high-risk subset.
CLL Cytogenetics and Molecular Prognostics
Made foundational contributions to understanding del(11q), del(17p), TP53 mutations, and IGHV status as CLL prognostic and predictive biomarkers, establishing the molecular basis for modern risk-adapted CLL therapy.
Representative Works 代表性著作
Venetoclax in Relapsed or Refractory Chronic Lymphocytic Leukaemia with 17p Deletion: a Multicentre, Open-Label, Phase 2 Study (M13-982)
Lancet Oncology (2016)
Pivotal trial demonstrating 79% response rate with venetoclax in del(17p) CLL, leading to FDA accelerated approval.
TP53 Mutations and Outcome in Chronic Lymphocytic Leukemia
Journal of Clinical Oncology (2014)
Comprehensive analysis of TP53 mutation impact on CLL prognosis and chemoimmunotherapy resistance, establishing TP53 as key treatment stratification biomarker.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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