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Translational Medicine / 转化医学Leukemia, Tisagenlecleucel ALL CAR-T

Stephan Grupp

MD, PhD

🏢Children's Hospital of Philadelphia🌐USA

Section Chief, Bone Marrow Transplant

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👥Biography 个人简介

Stephan Grupp led the pivotal trials that resulted in the first FDA approval of a CAR-T cell therapy, tisagenlecleucel, for pediatric and young adult relapsed/refractory B-cell ALL. His work on cytokine release syndrome pathophysiology and the use of tocilizumab to manage severe CRS has defined modern supportive care for CAR-T therapy. He continues to lead research into next-generation CAR-T constructs for ALL.

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🧪Research Fields 研究领域

tisagenlecleucel CAR-T ALL
pediatric ALL immunotherapy
CAR-T manufacturing
cytokine release syndrome management
pediatric B-ALL relapsed treatment

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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