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Translational Medicine / 转化医学Single-Cell Cancer Atlas

Oliver Stegle

PhD

🏢German Cancer Research Center (DKFZ)🌐Germany

Director of Computational Biology

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👥Biography 个人简介

Oliver Stegle has developed Bayesian statistical methods for analyzing single-cell multi-omics data that enable joint modeling of transcriptomic, epigenomic, and genetic variation in cancer cells. His computational approaches for spatial transcriptomics analysis have been critical for mapping the spatial architecture of tumor ecosystems. His work on clonal evolution from single-cell data has revealed how genetic and epigenetic heterogeneity co-evolve during cancer progression and treatment.

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🧪Research Fields 研究领域

Single-cell multi-omics methods
Spatial transcriptomics analysis
Cancer clonal evolution single-cell
Bayesian single-cell models
Epigenomic heterogeneity cancer

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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