Stefan Sleijfer
斯特凡·斯莱杰弗
MD, PhD
Professor of Oncology肿瘤学教授
👥Biography 个人简介
Stefan Sleijfer is a translational oncologist who has pioneered circulating tumor cell (CTC) biology research and clinical applications across multiple cancer types. His laboratory has characterized CTC heterogeneity, epithelial-mesenchymal plasticity, and metastasis biology using single-cell CTC analysis. Sleijfer led major European liquid biopsy validation studies and has contributed to CTC-based biomarker use in metastatic breast, colorectal, and prostate cancer. His work bridges fundamental CTC biology with clinical monitoring applications and companion diagnostic development for targeted therapies.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
CTC Heterogeneity Characterization
Characterized molecular heterogeneity among CTCs at the single-cell level, revealing epithelial-mesenchymal plasticity and identifying distinct CTC subpopulations with differential metastatic potential.
European Liquid Biopsy Validation
Led prospective validation studies of CTC-based biomarkers in European breast and colorectal cancer cohorts, contributing to international consensus on liquid biopsy clinical utility.
Representative Works 代表性著作
CTC Enumeration and Characterization in Metastatic Breast Cancer
Annals of Oncology (2014)
Prospective validation of CTC biomarker utility in metastatic breast cancer.
Single-Cell Analysis of CTCs from Advanced Cancer Patients
Nature Medicine (2016)
Single-cell characterization of CTC heterogeneity and EMT plasticity.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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