Stefan Pfister
斯特凡·普菲斯特
MD
Division Head, Pediatric Neurooncology儿童神经肿瘤科部门主任
👥Biography 个人简介
Stefan Pfister is a preeminent pediatric neuro-oncologist at DKFZ Heidelberg who revolutionized brain tumor classification through DNA methylation profiling, co-led landmark medulloblastoma subgroup genomics studies, and founded the Heidelberg Brain Tumor Reference Center serving global diagnostics.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
DNA Methylation Brain Tumor Classification
Co-developed the DKFZ DNA methylation classifier for CNS tumors, a paradigm-shifting tool now used worldwide to precisely classify over 150 brain tumor entities from a single assay.
Medulloblastoma Genomics
Co-led international genomic studies defining medulloblastoma's four molecular subgroups (WNT, SHH, Group 3, Group 4) and their distinct driver mutations and clinical outcomes.
Pediatric Glioma Epigenomics
Identified recurrent histone H3 mutations (H3K27M, H3G34R/V) in pediatric high-grade gliomas, establishing new tumor entities with distinct biological and clinical properties.
Representative Works 代表性著作
DNA methylation-based classification of central nervous system tumours
Nature (2018)
Landmark study introducing genome-wide DNA methylation profiling as the gold standard for objective CNS tumor classification.
Subgroup-specific structural variation across 1,000 medulloblastoma genomes
Nature (2022)
Comprehensive structural genomic analysis of 1,000 medulloblastomas revealing subgroup-specific vulnerabilities and therapeutic targets.
K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas
Acta Neuropathologica (2012)
Identified H3.3 K27M as a hallmark mutation in DIPG with prognostic significance.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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留下邮箱，当我们发布与 Stefan Pfister（German Cancer Research Center (DKFZ) / Heidelberg University Hospital）相关的新研究或访谈时，我们会通知你。
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