Stefan Michiels
斯蒂芬·米凯尔斯
PhD
Head, Biostatistics and Epidemiology Unit; Professor of Biostatistics, Paris-Saclay University生物统计学与流行病学部主任；巴黎-萨克雷大学生物统计学教授
👥Biography 个人简介
Stefan Michiels, PhD is a leading European oncology biostatistician at Gustave Roussy, recognized globally for his work on surrogate endpoint validation, meta-analysis methodology, and statistical innovation in immunotherapy and radiotherapy clinical trials. He leads the LNCC-accredited biostatistics unit at Europe's largest cancer center.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Surrogate Marker Validation in Oncology Trials
Made major contributions to the statistical methodology for validating surrogate endpoints in oncology, particularly for immunotherapy and locoregional treatments, using individual patient data meta-analysis approaches.
Immunotherapy Clinical Trial Biostatistics
Developed novel statistical methods addressing the unique challenges of immunotherapy trial design, including non-proportional hazards, delayed effects, and long-term survivor analysis.
Representative Works 代表性著作
Evaluating the Surrogate Value of Pathological Complete Response for Overall Survival (EBCTCG Collaborative Study)
The Lancet Oncology (2020)
Large-scale meta-analysis validating pathological complete response as a surrogate for survival in neoadjuvant breast cancer trials across diverse molecular subtypes.
Meta-Analytic Validation of Surrogate Endpoints for Immunotherapy in Non-Small Cell Lung Cancer
Journal of Clinical Oncology (2022)
Comprehensive individual-patient-data meta-analysis establishing the validity of PFS as a surrogate for OS in first-line immunotherapy NSCLC trials.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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