Stefan Knapp

Stefan Knapp at Goethe University and the Structural Genomics Consortium has been a pioneer in developing high-quality chemical probes for kinases and epigenetic regulators to enable reproducible biological research. His work has contributed to the characterization of kinase selectivity profiles through comprehensive biochemical and cellular profiling. He has been instrumental in the open-science chemical probe program that made selective reagents freely available for the academic research community. His structural work on kinase-inhibitor interactions has provided mechanistic insights into selectivity and has guided medicinal chemistry for multiple kinase inhibitor programs.