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Translational Medicine / 转化医学Structural Biology, Kinase Inhibitors

Stefan Knapp

PhD

🏢Goethe University Frankfurt🌐Germany

Professor of Pharmaceutical Chemistry

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Key Contributions

👥Biography 个人简介

Professor Stefan Knapp is one of the world's leading structural biologists focused on kinase and epigenetic drug targets. He pioneered the chemical probe approach to target validation and has solved hundreds of crystal structures of kinases and epigenetic readers. His work on bromodomain structural biology and chemical probes catalyzed the BET inhibitor field and informed the design of highly selective allosteric kinase inhibitors for cancer therapy.

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🧪Research Fields 研究领域

allosteric kinase inhibitor structural biology
bromodomain epigenetic drug targets
chemical probe development cancer
kinase selectivity structural basis
type II kinase inhibitors

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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