Nathaniel Snyder

Nathaniel Snyder has elucidated the connections between cancer metabolism and epigenetic regulation, demonstrating that acetyl-CoA metabolism directly controls histone acetylation patterns that drive oncogenic gene expression programs. His metabolomics approaches for measuring metabolite-epigenome crosstalk have revealed how metabolic reprogramming in cancer rewires the epigenetic landscape. His work on cancer metabolism-epigenetics integration has identified metabolic interventions that can reprogram the cancer epigenome for therapeutic benefit.