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Translational Medicine / 转化医学Neuroendocrine Tumors

Simron Singh

西姆伦·辛格

MD, MPH, FRCPC

🏢Sunnybrook Health Sciences Centre, University of Toronto(阳光溪健康科学中心,多伦多大学)🌐Canada

Head, Division of Medical Oncology; Medical Director, Susan Leslie Clinic for Neuroendocrine Tumours肿瘤内科部门主任,苏珊·莱斯利神经内分泌肿瘤诊所医疗主任

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h-index
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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Simron Singh, MD, MPH, FRCPC is Head of Medical Oncology at Sunnybrook Health Sciences Centre and Medical Director of the Susan Leslie Clinic for Neuroendocrine Tumours at the University of Toronto, the largest NET program in Canada. She is internationally recognized for her patient-centered research integrating health-related quality of life, patient-reported outcomes (PROs), and health services perspectives into NET clinical trials and clinical practice. Her work has demonstrated that carcinoid syndrome significantly impairs quality of life beyond diarrhea alone and has informed PRO endpoint design in pivotal NET trials including the TELECAST program. Dr. Singh has led prospective studies characterizing the lived experience of NET patients, including the impact of carcinoid syndrome on daily functioning, employment, and psychological wellbeing — areas largely invisible to traditional trial endpoints. She co-founded the Canadian NET Registry, a national prospective database enabling population-based studies of NET incidence, treatment patterns, and disparities in access across Canada's healthcare system. Her health equity research has revealed socioeconomic and geographic barriers to NET specialty care and novel therapies, motivating advocacy for improved access. A highly engaging educator and patient advocate, Dr. Singh is a past president of NANETS and a board member of the Carcinoid Cancer Foundation. She has published over 150 peer-reviewed articles and is a frequent voice for patients with NETs at international oncology meetings.

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🧪Research Fields 研究领域

Patient-Reported Outcomes in NETs
Carcinoid Syndrome Quality of Life
Health Services Research in NETs
Telotristat Clinical Development
Canadian NET Registry
Health Equity in Oncology

🎓Key Contributions 主要贡献

Patient-Reported Outcomes and Quality of Life Research in NETs

Conducted the most comprehensive prospective studies of health-related quality of life and patient-reported outcomes in NETs, demonstrating that carcinoid syndrome impairs multiple functional domains — fatigue, social functioning, psychological wellbeing — beyond bowel symptoms, and establishing validated PRO instruments now incorporated into NET trial designs.

Canadian NET Registry: National Epidemiology and Outcomes Database

Co-founded and leads the Canadian NET Registry, a national prospective database of NET patients from all Canadian provinces enabling landmark analyses of incidence trends, treatment access disparities, and survival outcomes at a population level, informing Canadian health policy and healthcare planning for NET patients.

Health Equity and Access to NET Therapy in Canada

Led investigations documenting socioeconomic, geographic, and systemic disparities in access to NET specialist care, PRRT, and novel agents across Canadian provinces, generating the first national evidence base motivating policy interventions to improve equitable access for NET patients.

Representative Works 代表性著作

[1]

Patient-Reported Outcomes in Patients with Carcinoid Syndrome from Midgut NETs: Systematic Review

Therapeutic Advances in Gastroenterology (2020)

Comprehensive systematic review of PRO measurement instruments and health-related quality of life data in carcinoid syndrome, establishing a framework for PRO endpoint selection in future NET clinical trials.

[2]

Quality of Life in Patients with Neuroendocrine Tumors: A Systematic Review

Journal of Clinical Oncology (2014)

Systematic review synthesizing quality of life evidence across NET subtypes and treatments, demonstrating the multidimensional impact of NETs and carcinoid syndrome on patient functioning and informing patient-centered care standards.

[3]

Incidence and Survival Trends for Neuroendocrine Tumors in Ontario, Canada

Endocrine Oncology (2022)

Population-based analysis using Ontario administrative data characterizing 20-year trends in NET incidence and survival, demonstrating dramatic increases in incidence and improving stage-specific outcomes reflecting earlier detection and improved therapy.

🏆Awards & Recognition 奖项与荣誉

🏆NANETS President (past)
🏆Canadian Institute of Health Research (CIHR) New Investigator Award
🏆University of Toronto Department of Medicine Excellence in Research Award
🏆Carcinoid Cancer Foundation Medical Advisory Board

📄Data Sources 数据来源

Last updated: 2026-04-06 | All information from publicly available academic sources

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