Silvia Stacchiotti
西尔维娅·斯塔基奥蒂
MD
Senior Medical Oncologist, Adult Mesenchymal Tumor Unit成人间叶肿瘤科高级肿瘤内科医师
👥Biography 个人简介
Silvia Stacchiotti, MD is a Senior Medical Oncologist at INT Milan and the world's leading clinical expert on chordoma and alveolar soft part sarcoma (ASPS). She established the international chordoma treatment community and led consensus guidelines development. Her work on PDGFR inhibition in chordoma and MET/TFE3 targeting in ASPS has transformed management of these ultra-rare tumors.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Chordoma Therapy
Established clinical activity of imatinib and other PDGFR/EGFR inhibitors in chordoma through prospective trials, leading international consensus guidelines that define global standard-of-care for this rare bone and STS tumor.
Alveolar Soft Part Sarcoma
Led the clinical development of antiangiogenic and MET-targeted therapy in ASPS, and contributed to the first phase II immunotherapy trials showing exceptional responses to anti-PD-1 therapy in this translocation-driven STS.
Representative Works 代表性著作
Chordoma: The Entity
Modern Pathology (2020)
Definitive review of chordoma biology, molecular drivers, and treatment strategies that serves as the field's key reference document.
Antiangiogenic Treatment for Alveolar Soft-Part Sarcoma: A Retrospective Analysis and Review of the Literature
Annals of Oncology (2016)
Demonstrated high response rates to antiangiogenic agents in ASPS and defined the therapeutic algorithm prior to the immunotherapy era.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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