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Translational Medicine / 转化医学Radiation Biology, Abscopal Effect Mechanism

Silvia Formenti

MD

🏢Weill Cornell Medicine🌐USA

Chairman, Department of Radiation Oncology

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Key Contributions

👥Biography 个人简介

Silvia Formenti has been the foremost investigator of the abscopal effect of radiotherapy and its immunological basis. She and Sandra Demaria established the conceptual and experimental framework demonstrating that localized radiation can convert tumors into in situ vaccines when combined with immune adjuvants. Her clinical work has pioneered combination trials of SBRT with CTLA-4 and PD-1 blockade.

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🧪Research Fields 研究领域

abscopal effect radiation immunotherapy
radiation immune priming
radiation TGF-beta checkpoint
stereotactic radiation IO combination
radiation-induced immunogenic cell death

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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