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Translational Medicine / 转化医学Prostate Cancer Advanced 2026

Silke Gillessen

西尔克·吉莱森

MD

🏢Istituto Oncologico della Svizzera Italiana (IOSI)(瑞士意大利肿瘤研究所)🌐Switzerland

Head, Genitourinary Oncology and Lead Investigator, Prostate Cancer Trials泌尿肿瘤科主任及前列腺癌试验首席研究员

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Prof. Silke Gillessen is a leading European prostate cancer specialist at IOSI Switzerland and co-chair of the Advanced Prostate Cancer Consensus Conference (APCCC). She contributed to the ENZAMET trial establishing enzalutamide in mHSPC, and convenes international consensus panels defining global standards for advanced prostate cancer management.

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🧪Research Fields 研究领域

mHSPC转移性激素敏感性前列腺癌
mCRPC转移性去势抵抗性前列腺癌
ENZAMET trialENZAMET试验
Prostate cancer multidisciplinary care前列腺癌多学科诊疗
International Consensus国际共识

🎓Key Contributions 主要贡献

Enzalutamide in mHSPC (ENZAMET)

Contributed to the ENZAMET phase III trial establishing enzalutamide plus ADT as a survival-improving standard of care in metastatic hormone-sensitive prostate cancer, especially in the context of docetaxel combinations.

Advanced Prostate Cancer Consensus Conference

Co-founded and co-chairs the biennial APCCC, synthesizing global expert consensus on management of advanced prostate cancer to guide clinicians worldwide, producing highly cited consensus recommendations since 2017.

Representative Works 代表性著作

[1]

Enzalutamide with Standard First-Line Therapy in Metastatic Prostate Cancer (ENZAMET)

New England Journal of Medicine (2019)

Phase III trial demonstrating enzalutamide plus ADT significantly improved OS in mHSPC regardless of concurrent docetaxel use.

[2]

Management of Patients with Advanced Prostate Cancer: Report of the Advanced Prostate Cancer Consensus Conference 2022

European Urology (2023)

Consensus recommendations from APCCC 2022 covering treatment sequencing, biomarker use, and emerging therapies in advanced prostate cancer.

🏆Awards & Recognition 奖项与荣誉

🏆Swiss Cancer Research Foundation Award
🏆ESMO Prostate Cancer Research Recognition Award
🏆European Association of Urology Distinguished Contributor Award

📄Data Sources 数据来源

Last updated: 2026-01-15 | All information from publicly available academic sources

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