Shimon Sakaguchi
MD PhD
Distinguished Professor
👥Biography 个人简介
Shimon Sakaguchi at Osaka University discovered regulatory T cells (Tregs) marked by Foxp3 expression — a discovery that fundamentally changed immunology by explaining how the immune system maintains self-tolerance and how cancer exploits Treg-mediated immunosuppression. His work demonstrating that tumor-infiltrating Tregs suppress anti-tumor immunity provided the rationale for anti-CTLA-4 therapy's mechanism of depleting intratumoral Tregs, and for Treg-depleting strategies as cancer immunotherapy.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Representative Works 代表性著作
📄Data Sources 数据来源
Last updated: 2026-03-01 | All information from publicly available academic sources
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