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Translational Medicine / 转化医学Breast Cancer

Sherene Loi

谢伦·洛伊

MBBS (Hons), PhD, FRACP

🏢Peter MacCallum Cancer Centre, University of Melbourne(墨尔本大学彼得麦卡勒姆癌症中心)🌐Australia

Professor and Head, Translational Breast Cancer Genomics and Immunology Lab转化乳腺癌基因组学与免疫学实验室教授及主任

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

World-leading translational researcher at Peter MacCallum Cancer Centre, pioneering tumor infiltrating lymphocyte (TIL) scoring as a prognostic and predictive biomarker in TNBC and HER2+ breast cancer, enabling precision immunotherapy selection.

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🧪Research Fields 研究领域

Breast Cancer乳腺癌
TNBC三阴性乳腺癌
Tumor Infiltrating Lymphocytes肿瘤浸润淋巴细胞
Immunotherapy免疫治疗
Breast Cancer Genomics乳腺癌基因组学

🎓Key Contributions 主要贡献

Tumor Infiltrating Lymphocytes in Breast Cancer

Established TIL scoring as a validated biomarker for prognosis and immunotherapy response in TNBC, co-developing international guidelines for TIL assessment now used in clinical practice worldwide.

Representative Works 代表性著作

[1]

Tumor-Infiltrating Lymphocytes and Prognosis: A Pooled Individual Patient Analysis of Early-Stage Triple-Negative Breast Cancers

Journal of Clinical Oncology (2019)

Pooled analysis establishing TIL levels as independent prognostic factor for TNBC, showing each 10% TIL increase associated with improved survival.

🏆Awards & Recognition 奖项与荣誉

🏆NHMRC Investigator Grant (Leadership Level)
🏆ESMO Translational Research Award
🏆Australian Cancer Research Foundation Award

📄Data Sources 数据来源

Last updated: 2026-01-15 | All information from publicly available academic sources

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