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Translational Medicine / 转化医学ROS1 Fusion Resistance Mechanisms

Alice Shaw

MD, PhD

🏢Novartis Oncology🌐USA

Vice President, Global Development

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Key Contributions

👥Biography 个人简介

Alice Shaw pioneered the clinical development of ALK and ROS1-targeted therapies and discovered key resistance mechanisms to crizotinib in ROS1-positive NSCLC. Her work on lorlatinib established it as an effective agent against ROS1 resistance mutations. She has transitioned from academic leadership at Mass General to industry drug development.

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🧪Research Fields 研究领域

ROS1 fusions
ALK rearrangements
Lorlatinib
Drug resistance
Targeted therapy

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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